Recent Development in the Technology of Fischer Indole Synthesis Fischer吲哚合成法的研究进展
Study on Fischer Indole Synthesis Catalyzed by Hollow Molecular Sieves 中孔分子筛催化Fischer吲哚合成的研究
Methods 2-naphthylhydrazine was prepared from 2-naphthylamine via diazotization and reduction reactions, followed by a Fischer indole synthesis with isopropyl methyl ketone to give 1,1,2-trimethyl-1H-benz [ e] indole. 方法由2-萘胺经重氮化反应、还原反应制得2-萘肼,再与甲基异丙基酮经费歇尔吲哚合成反应制得目标化合物。
One of the main reasons is the lack of regioselectivity in the traditional Fischer indole synthesis, when unsymmetrical ketones are taken as substrates. 造成这种现象的一个很重要的原因是传统Fischer吲哚合成法以非对称的酮作为底物时存在的区域选择性问题。